Semax Compound

FIELD LOG / SOURCES

Semax References

Every study cited across this field log, with PubMed and PMC links and DOIs. The record this site reads from.

The researchReported effects

About these sources

Every quantitative claim on this site maps to one of the sources below, numbered to match the inline [N] markers on each page. The list is dominated by Russian-led preclinical work in rats and mice, with a small number of human EEG, clinical, and imaging studies — an accurate reflection of where the Semax literature actually sits. Where a DOI exists it is given; where one is not available, the PubMed identifier links the record. This is a reading list, not a course of treatment.

  1. Dolotov OV, et al. Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006;97 Suppl 1:82-6. ↗
  2. Agapova TY, et al. Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH(4-10). Neurosci Lett. 2007;417(2):201-5. ↗
  3. Kost NV, et al. Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorg Khim (Russ J Bioorg Chem). 2001;27(3):180-183. ↗
  4. Romanova GA, et al. Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex. Bull Exp Biol Med. 2006;142(6):663-6. ↗
  5. Medvedeva EV, et al. The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics. 2014;15:228. ↗
  6. Shevchenko KV, et al. Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration. Russ J Bioorg Chem (Bioorg Khim). 2006;32(1):57-62. ↗
  7. Semax peptide targets the mu opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice. Br J Pharmacol. 2025. ↗
  8. Eremin KO, et al. Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005;30(12):1493-1500. ↗
  9. Dolotov OV, et al. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006;1117(1):54-60. ↗
  10. Manchenko DM, et al. Semax prevents learning and memory inhibition by heavy metals. Dokl Biol Sci. 2016;468(1):100-102. ↗
  11. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020;490(1):11-14. ↗
  12. Effect of Semax peptide on survival of cultured rat pheochromocytoma cells during oxidative stress. Bull Exp Biol Med. 2003;135(3):235-238. ↗
  13. Effect of the heptapeptide Semax on the human electroencephalogram. Biull Eksp Biol Med. 1996;121(1):26-30. ↗
  14. Evaluation of therapeutic effect of new Russian drug semax in optic nerve disease. Vestn Oftalmol. 2000;116(1):54-57. ↗
  15. Shevchenko KV, et al. Stability of Semax acetyl to proteolysis in various biological media. Dokl Biol Sci. 2013;449:98-100. ↗
  16. The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease. Acta Naturae. 2025. ↗